SWOV Catalogus

340479

Evaluation of four oral fluid devices (DDS®, Drugtest 5000®, Drugwipe 5+® and RapidSTAT®) for on-site monitoring drugged driving in comparison with UHPLC–MS/MS analysis.
20150108 ST [electronic version only]
Strano-Rossi, S. Castrignanò, E. Anzillotti, L. Serpelloni, G. Mollica, R. Tagliaro, F. Pascali, J.P. di Stefano, D. Sgalla, R. & Chiarotti, M.
Forensic Science International, Vol. 221 (2012), Nos. 1-3 (September), p. 70-76, 20 ref.

Samenvatting New Italian legislation on driving under the influence of drugs considers oral fluid (OF) as a possible alternative drug testing matrix. On this basis, the present research was carried out to evaluate the applicability of four commercial on-site OF drug screening devices, namely DDS®, Drugtest 5000®, Drugwipe 5+® and RapidSTAT®, in a real operative context. Preliminarily trained police officers tested randomly stopped drivers with two different kits side-by-side during roadside patrols. A central laboratory confirmed on-site kits’ results by UHPLC–MS/MS analysis of the saliva specimen remaining after the screening analysis. 1025 drivers were submitted to the OF tests: 11.6% were positive for cocaine and metabolites, 11.1% for THC, 6% for amphetamines and amphetamine-type designer drugs and 2.3% for ketamine. The sensitivities of the kits were 81% (RapidSTAT®), 82% (DDS®), 90% (Drugwipe 5+®) and 97% (Drugtest 5000®) for cocaine and 38% (DDS®), 47% (Drugwipe 5+®), 72% (RapidSTAT®) and 92% (Drugtest 5000®) for THC. Drugtest 5000 was the only kit showing an acceptable sensitivity for on-site application. Only Drugtest 5000® and RapidSTAT® could be evaluated for amphetamines and methamphetamines: Drugtest 5000® showed a sensitivity of 100% in the case of amphetamines and 86% for methamphetamines, while RapidSTAT® 90% and 76% respectively. Nowadays, ketamine is not included in the target analytes of any on-site devices, but it was systematically included in the UHPLC–MS/MS confirmatory analysis. To ensure adequate reliability, MS confirmation of on-site OF screening tests is anyway always necessary, due to the presence of a significant number of false positive results even when using the commercial kit with the best performance. (Author/publisher)
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